Автор: http://www.swissdelphicenter.ch

function GetCheckSum(FileName: string): DWORD;
var
  F: file of DWORD;
  P: Pointer;
  Fsize: DWORD;
  Buffer: array[0..500] of DWORD;
begin
  FileMode := 0;
  AssignFile(F, FileName);
  Reset(F);
  Seek(F, FileSize(F) div 2);
  Fsize := FileSize(F) - 1 - FilePos(F);
  if Fsize > 500 then
    Fsize := 500;
  BlockRead(F, Buffer, Fsize);
  Close(F);
  P := @Buffer;
  asm
     xor eax, eax
     xor ecx, ecx
     mov edi , p
     @again:
       add eax, [edi + 4*ecx]
       inc ecx
       cmp ecx, fsize
     jl @again
     mov @result, eax
  end;
end;

procedure TForm1.Button1Click(Sender: TObject);
begin
  ShowMessage(IntToStr(GetCheckSum('c:\Autoexec.bat')));
end;